The project involves the development of a prototype for a smart point of care pharmacogenetic testing device. OneDrug Inc. aims to create a device that enables healthcare providers to quickly identify patients who may experience adverse drug reactions due to genetic variations. This device will facilitate personalized treatment plans, improving patient outcomes and reducing healthcare costs. The project will focus on integrating genetic data analysis with user-friendly technology to ensure rapid and accurate results. The team will apply their knowledge of genetics, biomedical engineering, and software development to create a functional prototype that meets industry standards. Key tasks include designing the device interface, developing the genetic analysis algorithm, and testing the prototype for accuracy and reliability.

We have created a development pathway for our smart point of care pharmacogenetic testing device and are looking forward to its implementation.

Student developers will work on:

Hardware Component:

Project Description:

The hardware component of this project aims to create an advanced pharmacogenetic testing device by integrating cutting-edge technologies for DNA amplification and microfluidics.

Key Hardware Features:

Amplification Technology Integration:

• Implement advanced DNA amplification technology for sensitive and specific detection of genetic variations relevant to drug processing.

Microfluidic Design:

• Develop microfluidic channels to optimize sample handling, reagent delivery, and reaction efficiency, ensuring precise control over fluid flow for enhanced genetic testing performance.

Portability and Flexibility:

• Design the hardware with portability in mind, allowing for usage in various settings, including point-of-care environments, clinics, and remote healthcare facilities.

Sample Versatility:

• Ensure the device can process various sample types, accommodating different biological materials commonly encountered in genetic testing.

Software Component:

Project Description:

The software component of this project focuses on creating a sophisticated platform to control device operations, collect, analyze genetic data, and provide actionable insights.

Key Software Features:

Device Control and Data Collection:

• Develop software to control device operations, manage data collection and storage, and ensure seamless communication between the hardware and software components.

User-Friendly Interfaces:

• Design intuitive interfaces for both healthcare professionals and patients, providing easy access to genetic data, test results, and personalized treatment recommendations.

Data Security Measures:

• Implement robust security measures to protect patient genetic data, ensuring compliance with healthcare data protection regulations.

Real-time Data Analysis:

• Enable real-time analysis of genetic data, allowing healthcare professionals to make informed decisions promptly.

Technologies:

The following technologies and tools are essential for the successful execution of this project:

1. Microcontrollers: Arduino, Raspberry Pi, or equivalent for hardware control.
2. Biomedical Sensors: Sensors for genetic variations and relevant parameters.
3. Microfluidic Components: Pumps, valves, and chambers for microfluidic design.
4. Electronic Design Tools: CAD tools (Altium, Eagle, KiCad) for electronic circuit design.
5. Prototyping Tools: Prototyping boards and components.
6. Laboratory Equipment: Basic lab equipment for experimental work.
7. Programming Languages: Proficiency in C, C++, Python, or relevant languages.
8. Embedded IDE: Development environments like Arduino IDE or PlatformIO.
9. UI Development Tools: Tools for developing user interfaces (Qt, etc.).
10. Real-Time Data Analysis: Software tools or libraries for data analysis.
11. Version Control: Git for codebase management.
12. Documentation Tools: Markdown editors, LaTeX, or Word for documentation.
13. Data Security Tools: Measures and tools for data security.
14. 3D Printer: For rapid prototyping and custom component creation.
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NDA and IP agreements apply to this exciting project.

Student Learning Experience

Participating in the development of a smart point of care pharmacogenetic testing device can offer students a range of valuable learning experiences. Here are five potential learning outcomes for students involved in this project:

Interdisciplinary Collaboration:

• Experience: Collaborating with professionals from diverse fields, including hardware engineering, microfluidics, software development, and healthcare.
• Learning Outcome: Enhanced ability to work in interdisciplinary teams, understanding and appreciating the contributions of various disciplines to achieve a common goal.

Advanced Technology Integration:

• Experience: Integrating cutting-edge technologies such as advanced DNA amplification, microfluidics, and real-time data analysis.
• Learning Outcome: Gaining practical skills in incorporating advanced technologies into a cohesive and functional system, fostering adaptability to emerging innovations.

Hardware-Software Integration:

• Experience: Integrating hardware components with software systems for seamless control, data collection, and real-time analysis.
• Learning Outcome: Developing proficiency in bridging the gap between hardware and software, an essential skill in modern technological projects.

User-Centric Design:

• Experience: Designing user-friendly interfaces for both healthcare professionals and patients.
• Learning Outcome: Understanding the importance of user-centric design principles in healthcare technology, considering usability and accessibility for diverse end-users.

Regulatory Compliance Awareness:

• Experience: Navigating considerations for data security and compliance with healthcare data protection regulations.
• Learning Outcome: Gaining awareness of regulatory requirements in healthcare technology projects, understanding the importance of data security and privacy in medical applications.

Students will participate in a weekly virtual progress report meetings with stakeholders.

Expected Deliverables

Expected Hardware Outcomes:

1. A functional prototype of the pharmacogenetic testing device integrating advanced DNA amplification technology and microfluidics.
2. Demonstrated capability for rapid and accurate genetic testing, emphasizing portability and versatility.
3. Comprehensive documentation detailing the hardware design, including schematics, component specifications, and assembly instructions.
4. A report demonstrating the device's capabilities, including sensitivity, specificity, reaction efficiency, and portability.

Expected Software Outcomes:

1. A fully functional software platform interfacing with the hardware for seamless control, data collection, and analysis.
2. User-friendly interfaces tailored for both healthcare professionals and patients.
3. Demonstrated data security measures to protect sensitive genetic information.
4. Documentation outlining the robust security measures implemented in the software to protect patient genetic data, ensuring compliance with healthcare data protection regulations.
5. Documentation highlighting the seamless integration between the hardware and software components, with details on data flow and communication protocols.